RT.Coat L30D (methacrylic acid-ethyl acrylate copolymer)
The absorption of drugs into the body in the traditional way has problems and limitations. For this reason, researchers have been looking for ways to solve the problems to a large extent. Following of these efforts, controlled drug delivery systems were introduced. The most important of these benefits include the ability to maintain a relatively constant concentration of drug for a specified period, the ability to adjust the drug release speed depending on the delivery location, the ability to deliver the drug to a specific organ or tissue, the ability to deliver multiple medicines with a formulation, the possibility of drug delivery in Nanometer dimensions, etc. These systems have revolutionized the treatment of many diseases and are increasing in number. One of these effective compounds in this field is acrylic copolymer. Pharmaceutical Co., Ltd is proud to be the first producer of methacrylic acid-ethyl acrylate copolymer brand RT.Coat in Iran as a knowledge base company. This product is known by the name Odurajit in the world.
Figure 1. RT.Coat molecular structure
RT.COAT is supplied to the company in the form of physical Disperse Blue RT.Coat L30D and powder RT.coat L100-55.
Exterior Features RT.Coat L30D
1. Milky emulsion with low viscosity
2. Scented, slightly aromatic
3. Content 28.5 - 31.5% by weight of dry polymer
4- Ability to dilute with water and soluble in organic and acetone alcohols
5. Non-toxic and safe for oral use due to high molecular weight and non-absorption by body tissues.
The ratio of carboxyl groups to ester groups in this product is 1: 1. RT.Coat is known according to the USP standard as the type C methacrylic acid copolymer.
RT.Coat L30D is the main ingredient used in coated oral pills and pellets that need to be opened in the intestinal base environment.
Figure 2. Opening of L30D RT.Coat tablets in the intestinal environment (duodenum).
RT.Coat L30D films are insoluble in acidic acidic stomach and dissolved in the intestinal environment with pH 5.5 and higher due to the formation of alkaline salts. The RT.Coat L30D film is colorless, transparent and fragile, which can be used to improve the elasticity of plastidizers such as polyethylene glycol, triethyl citrate, etc. in a coated formulation of 10 to 25%. Due to the fact that the base system is blue, the plastidizer must also be water-soluble.